NeuroscienceNature CommunicationsPeer-reviewed
TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients
Bruno Ghirotto, Luís Eduardo Gonçalves, Vivien Ruder…·Beate Winner
This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.
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