ImmunologybioRxiv
The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling
A. O. Smirnova, A. M. Miroshnichenkova, Y. V. Olshanskaya…·A. Y. Komkov
The paper introduces a method to correct PCR bias in immune repertoire sequencing by using non-functional clonotypes as a calibrator, improving accuracy across different sequencing approaches.
DOI 10.7554/elife.69157