BiochemistrybioRxiv
Targeted protein degradation via intramolecular bivalent glues
O. Hsia, M. Hinterndorfer, A. D. Cowan…·A. Ciulli
This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.
DOI 10.1038/s41586-024-07089-6