Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype
I. M. Michelozzi, E. Gomez-Castaneda, R. V. C. Pohle, F. Cardoso-Rodriguez, J. Sufi, P. Puigdevall-Costa, M. Subraniyam, E. Kirtsios, A. Eddaoudi, S. W. Wu, A. Guvenel, J. Fisher, S. Ghorashian, M. A. Pule, C. J. Tape, , A. Giustacchini
The paper compares low-affinity and high-affinity CD19 CAR T-cells, finding that low-affinity CARs show enhanced activation and cytokine polyfunctionality due to antigen-dependent priming.
bioRxiv · Sep 22, 2020Cancer Biology