Author

C. J. Tape

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. Sufi· 4 shared P. Vlckova· 4 shared X. Qin· 3 shared C. Nattress· 2 shared J. Fisher· 2 shared S. E. Acton· 2 shared A. C. Benjamin· 1 shared A. Eddaoudi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCancer Biology

J. Sufi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation

X. Qin, F. C. Rodriguez, J. Sufi, P. Vlckova, J. Claus, C. J. Tape

The paper maps how oncogenic mutations and microenvironmental signals co-regulate colonic stem cell fate through single-cell analysis of organoid cultures.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology

OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity

D. Fowler, M. Barisa, A. Southern Navarrete, C. Nattress, E. Hawkins, E. Vassalou, A. Kanouta, J. Counsell, E. M. Rota, P. Vlckova, B. Draper, C. J. Tape, K. Chester, J. Anderson, J. Fisher

OPS-γδ cells, engineered to secrete opsonins and stabilized IL15, show enhanced cytotoxicity and bystander activation for solid tumor control.

bioRxiv · Oct 23, 2022 · PreprintImmunology

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

M. Ramos Zapatero, A. Tong, J. Sufi, P. Vlckova, F. Cardoso Rodriguez, C. Nattress, X. Qin, D. Hochhauser, S. Krishnaswamy, C. J. Tape

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype

I. M. Michelozzi, E. Gomez-Castaneda, R. V. C. Pohle, F. Cardoso-Rodriguez, J. Sufi, P. Puigdevall-Costa, M. Subraniyam, E. Kirtsios, A. Eddaoudi, S. W. Wu, A. Guvenel, J. Fisher, S. Ghorashian, M. A. Pule, C. J. Tape, , A. Giustacchini

The paper compares low-affinity and high-affinity CD19 CAR T-cells, finding that low-affinity CARs show enhanced activation and cytokine polyfunctionality due to antigen-dependent priming.

bioRxiv · Sep 22, 2020Cancer Biology

Single-Cell Signalling Analysis of Heterocellular Organoids

X. Qin, J. Sufi, P. Vlckova, P. Kyriakidou, S. E. Acton, V. S. W. Li, M. Nitz, C. J. Tape

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

bioRxiv · Nov 11, 2019Cell Biology

Conduit integrity is compromised during acute lymph node expansion

V. G. Martinez, V. Pankova, L. Krasny, T. Singh, I. J. White, A. C. Benjamin, S. Dertschnig, H. L. Horsnell, J. Kriston-Vizi, J. J. Burden, P. H. Huang, C. J. Tape, S. E. Acton

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

bioRxiv · Mar 21, 2019Immunology