Cancer BiologybioRxiv
Enhanced functionality of low-affinity CD19 CAR T-cells is associated with activation priming and a polyfunctional cytokine phenotype
I. M. Michelozzi, E. Gomez-Castaneda, R. V. C. Pohle…·A. Giustacchini
The paper compares low-affinity and high-affinity CD19 CAR T-cells, finding that low-affinity CARs show enhanced activation and cytokine polyfunctionality due to antigen-dependent priming.
DOI 10.1182/blood-2020-141249