Author

M. A. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Organism:virus· 1

Frequent Co-Authors

C. J. Jackson· 2 shared A. Aggarwal· 1 shared A. Norman· 1 shared A. T. Meger· 1 shared B. J. Bosch· 1 shared C. Franck· 1 shared D. A. A. van Dongen· 1 shared D. L. Hurdiss· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

C. J. Jackson

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Author profile →

2 papers

Recent·Most cited

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

V. Thijssen, D. L. Hurdiss, O. J. Debski-Antoniak, M. A. Spence, C. Franck, A. Norman, A. Aggarwal, N. J. Mokiem, D. A. A. van Dongen, S. W. Vermeir, M. Liu, W. Li, M. Chatziandreou, T. Donselaar, W. Du, , S. A. K. Jongkees

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

bioRxiv · Nov 11, 2022 · PreprintBiochemistry

Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors

A. T. Meger, M. A. Spence, M. Sandhu, C. J. Jackson, S. Raman

The paper characterizes the rugged fitness landscape of transcriptional repressors, showing rapid specificity switching and the role of regulatory crosstalk in shaping evolutionary paths.

bioRxiv · Oct 25, 2022Biochemistry