Author

A. Norman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Ecology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. J. Payne· 5 shared C. Franck· 3 shared K. Patel· 3 shared T. Passioura· 3 shared A. Aggarwal· 2 shared H. Suga· 2 shared J. K. Low· 2 shared J. Mackay· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersBiochemistry

R. J. Payne

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Airborne eDNA captures three decades of ecosystem biodiversity

A. R. Sullivan, E. Karlsson, D. Svensson, B. Brindefalk, J. Antonio Villegas, A. Mikko, D. Bellieny, A. B. Siddique, A.-M. Johansson, H. Grahn, D. Sundell, A. Norman, P.-A. Esseen, A. Sjodin, N. J. Singh, , P. Stenberg

The paper develops a method using airborne eDNA sequencing to monitor biodiversity over 34 years, detecting over 2,700 genera and revealing regional biodiversity declines.

bioRxiv · Dec 6, 2023Ecology

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

J. K. Low, K. Patel, P. Solomon, A. Norman, P. Pachl, N. Jones, R. J. Payne, T. Passioura, H. Suga, L. J. Walport, J. Mackay

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

bioRxiv · May 17, 2023Biochemistry

Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins

C. Franck, K. Patel, L. J. Walport, M. T. Christie, A. Norman, T. Passioura, R. J. Payne, H. Suga, J. P. Mackay

The paper discovers and characterizes cyclic peptides that selectively bind to the C-terminal bromodomains of BET family proteins, showing high potency and paralogue-specificity.

bioRxiv · Dec 25, 2022Biochemistry

Cross-linking mass spectrometry discovers, evaluates, and validates the experimental and predicted structural proteome

T. K. Bartolec, X. Vazquez-Campos, A. Norman, C. Luong, R. J. Payne, M. R. Wilkins, J. P. Mackay, J. K. K. Low

The paper combines cross-linking mass spectrometry with AI-based structure prediction to discover and validate protein and complex structures at proteome scale.

bioRxiv · Nov 16, 2022 · PreprintBiochemistry

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

V. Thijssen, D. L. Hurdiss, O. J. Debski-Antoniak, M. A. Spence, C. Franck, A. Norman, A. Aggarwal, N. J. Mokiem, D. A. A. van Dongen, S. W. Vermeir, M. Liu, W. Li, M. Chatziandreou, T. Donselaar, W. Du, , S. A. K. Jongkees

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

bioRxiv · Nov 11, 2022 · PreprintBiochemistry

Neonate personality affects early-life resource acquisition in a large social mammal

B. Amin, D. J. Jennings, A. Norman, A. Ryan, V. Ioannidis, A. Magee, H.-A. Haughey, A. Haigh, S. Ciuti

The paper examines how neonate personality traits in fallow deer influence resource acquisition strategies during early life, finding a trade-off between scanning and foraging time that develops over time.

bioRxiv · Mar 15, 2022Ecology

A Precision Medicine Approach to Metabolic Therapy for Breast Cancer in Mice

N. D. Akingbesote, A. Norman, W. Zhu, A. A. Halberstam, X. Zhang, J. R. Foldi, M. B. Lustberg, R. J. Perry

This study combines dapagliflozin with paclitaxel chemotherapy in mice, showing enhanced tumor response in some breast cancers based on insulin signaling mutation location.

bioRxiv · Dec 15, 2021Cancer Biology

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

A. Norman, C. Franck, M. Christie, P. Hawkins, K. Patel, A. Ashhurst, A. Aggarwal, J. K. Low, R. Siddiquee, C. Ashley, M. Steain, J. A. Triccas, S. G. Turville, J. Mackay, T. Passioura, R. J. Payne

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

ACS Central Science · Jun 23, 2021Peer-reviewedBiochemistry