A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels
M.-R. Ghovanloo, M. Abdelsayed, C. H. Peters, P. C. Ruben
This paper shows that the P1158S mutation in Nav1.4 makes skeletal muscle sodium channels sensitive to pH changes, leading to myotonia and periodic paralysis under acidic conditions.
bioRxiv · Jul 17, 2017Biophysics