Author

M.-R. Ghovanloo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

P. C. Ruben· 2 shared S. J. Goodchild· 2 shared A. D. Williams· 1 shared A. R. Watkins· 1 shared C. H. Peters· 1 shared C. J. Cohen· 1 shared D. Poburko· 1 shared F. Scott· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

P. C. Ruben

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4 papers

Recent·Most cited

Molecular pharmacology of selective NaV1.6 and dual NaV1.6 and NaV1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

S. J. Goodchild, N. G. Shuart, A. D. Williams, W. Ye, R. R. Parrish, M. Soriano, S. Thouta, J. Mezeyova, M. Waldbrook, R. A. Dean, T. Focken, M.-R. Ghovanloo, P. C. Ruben, F. Scott, C. J. Cohen, , J. Johnson

This paper introduces selective NaV1.6 and dual NaV1.6/NaV1.2 inhibitors that suppress excitatory neuronal activity ex vivo, showing selectivity over NaV1.1 and efficacy in seizure models.

bioRxiv · Aug 3, 2023Pharmacology & Toxicology

Inhibition of sodium conductance by cannabigerol contributes to a reduction of neuronal dorsal root ganglion excitability

M.-R. Ghovanloo, M. Estacion, P. zhao, S. Dib-Hajj, S. G. Waxman

This study investigates how CBG inhibits Nav channels in DRG neurons and shows it reduces excitability through state-dependent inhibition and functional selectivity.

bioRxiv · Sep 14, 2021 · PreprintPharmacology & Toxicology

Mechanism and effects of the skeletal muscle Nav1.4 inhibition by cannabidiol

M.-R. Ghovanloo, K. Choudhury, T. S. Bandaru, M. A. Fouda, K. Rayani, R. Rusinova, T. Phaterpekar, K. Nelkenbrecher, A. R. Watkins, D. Poburko, J. Thewalt, O. S. Andersen, L. Delemotte, S. J. Goodchild, P. Ruben

This study investigates how cannabidiol inhibits Nav1.4 channels in skeletal muscle by modulating membrane elasticity and directly interacting with the channel pore.

bioRxiv · Jun 30, 2020Biophysics

A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels

M.-R. Ghovanloo, M. Abdelsayed, C. H. Peters, P. C. Ruben

This paper shows that the P1158S mutation in Nav1.4 makes skeletal muscle sodium channels sensitive to pH changes, leading to myotonia and periodic paralysis under acidic conditions.

bioRxiv · Jul 17, 2017Biophysics