ATM and MSH2 control blunt DNA end joining in immunoglobulin class switch recombination
E. Sible, M. Attaway, G. Fiorica, G. Michel, J. Chaudhuri, B. Q. Vuong
This study shows that ATM and MSH2 cooperate to regulate non-homologous end joining during immunoglobulin class switch recombination, with their combined loss causing synthetic lethality and impaired CSR.
bioRxiv · Jul 28, 2022 · PreprintImmunology