G. Michel

Depletion of CX3CR1+ macrophages results in disrupted functionality and immune surveillance within epididymis and testis

This study shows that CX3CR1+ macrophages are essential for maintaining immune balance and epithelial integrity in the epididymis and testis, with their depletion leading to immune dysfunction and fertility issues.

Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence

This study shows that Bacillus cereus spores persist in the gut by evading immune responses and inducing amidases to dampen immunity, leading to bacterial growth and digestive symptoms.

Monitoring plasma nucleosome concentrations to measure of disease response and progression in dogs with hematopoietic malignancies.

This study measures plasma nucleosome concentrations in dogs with hematopoietic malignancies to assess treatment response and disease progression, finding higher concentrations correlate with worse outcomes.

ATM and MSH2 control blunt DNA end joining in immunoglobulin class switch recombination

This study shows that ATM and MSH2 cooperate to regulate non-homologous end joining during immunoglobulin class switch recombination, with their combined loss causing synthetic lethality and impaired CSR.

FGF10 triggers de novo alveologenesis in a BPD model: impact on the resident mesenchymal niche cells

This study shows that FGF10 administration rescues alveologenesis defects in a BPD mouse model by activating resident mesenchymal niche cells.

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.