Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
T. Hasegawa, T. Oka, H. G. Son, V. S. Oliver-Garcia, M. Azin, T. M. Eisenhaure, D. J. Lieb, N. Hacohen, S. Demehri
The paper shows that cytotoxic CD4+ T cells eliminate senescent fibroblasts by targeting HCMV-gB antigen expressed on these cells, reducing their accumulation in old skin.
bioRxiv · Mar 6, 2023Immunology