ImmunologybioRxiv
Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
T. Hasegawa, T. Oka, H. G. Son…·S. Demehri
The paper shows that cytotoxic CD4+ T cells eliminate senescent fibroblasts by targeting HCMV-gB antigen expressed on these cells, reducing their accumulation in old skin.
DOI 10.1016/j.cell.2023.02.033