Author

M. B. Maina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein sequence· 1

Frequent Co-Authors

G. Burra· 3 shared L. Serpell· 3 shared L. C. Serpell· 2 shared A. A. Adamu· 1 shared A. Amin· 1 shared A. H. Yakubu· 1 shared A. I. Abushouk· 1 shared A. I. Alkhamis· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

G. Burra

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Generation of an induced pluripotent stem cell line from a healthy adult indigenous Nigerian participant

Z. Muhammad, P. W. Brown, L. Babazau, A. I. Alkhamis, B. W. Goni, H. A. Nggada, K. M. Mbaya, S. Wray, I. H. Marte, C. Karch, L. Serpell, M. B. Maina

The paper generates an iPSC line from a healthy Nigerian individual to address the lack of diverse iPSC lines in biomedical research.

bioRxiv · Jul 21, 2023 · PreprintCell Biology

GNNQQNY: Methodology for biophysical and structural understanding of aggregation

G. Burra, M. B. Maina, L. C. Serpell, A. Thakur

This study describes a solubilisation protocol for GNNQQNY peptides that enables the study of amyloid fibril formation kinetics and thermodynamics.

bioRxiv · Jan 1, 2022 · PreprintBiophysics

Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates.

M. B. Maina, Y. Al-Hilaly, G. B. Burra, J. Rickard, C. Harrington, C. Wischik, L. Serpell

This study shows that DiY cross-linking promotes tau oligomer formation and prevents filament elongation without causing cell toxicity.

bioRxiv · Dec 7, 2020Biochemistry

Nucleation-dependent aggregation kinetics of Yeast Sup35 fragment GNNQQNY

G. Burra, M. B. Maina, L. C. Serpell, A. K. Thakur

This study experimentally validates the nucleation-dependent aggregation kinetics of the yeast prion protein fragment GNNQQNY, showing temperature-dependent nucleation efficiency and amyloid fiber formation.

bioRxiv · Jul 27, 2020Biophysics

20 years of African Neuroscience: Waking a sleeping giant

M. B. Maina, U. Ahmad, I. A. Harun, H. S. Kwairanga, F. E. Nasr, A. T. Salihu, A. I. Abushouk, A. Muhammad, M. A. Awadelkareem, A. Amin, A. Imam, I. D. Akinrinade, A. H. Yakubu, I. A. Azeez, Y. G. Mohammed, , T. Baden

The paper analyzes 21 years of African neuroscience publications, verifying African leadership and providing metrics to inform policy recommendations for supporting neuroscience research in Africa.

bioRxiv · Jun 3, 2020 · PreprintScientific Communication & Education

Dityrosine cross-link trapping of amyloid-β intermediates reveals that self-assembly is required for Aβ-induced cytotoxicity

M. B. Maina, K. Mengham, G. Burra, Y. A. Al-Hilaly, L. Serpell

This study shows DiY cross-linking stabilizes Aβ assemblies but does not induce toxicity, while oligomeric non-cross-linked Aβ is toxic to neuroblastoma cells.

bioRxiv · Mar 25, 2020 · PreprintBiochemistry