Author

Y. Al-Hilaly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

C. Harrington· 2 shared C. Wischik· 2 shared L. C. Serpell· 2 shared C. J. Serpell· 1 shared C. M. Wischik· 1 shared G. B. Burra· 1 shared G. Burra· 1 shared J. Rickard· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

C. Harrington

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivMay 28, 2022

Dityrosine cross-links are present in Alzheimer's disease-derived tau oligomers and paired helical filaments (PHF) which promotes the stability of PHF-core tau (297-391) in vitro.

M. Maina, Y. Al-Hilaly, S. Oakley…·L. C. Serpell

This study shows dityrosine crosslinks are present in Alzheimer's disease tau oligomers and paired helical filaments, increasing their stability in vitro.

DOI 10.1016/j.jmb.2022.167785

humanproteomics

𝕏 PostBluesky

BiophysicsbioRxivOct 19, 2021

Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy image analysis

L. Lutter, Y. Al-Hilaly, C. J. Serpell…·W.-F. Xue

This paper develops a method to identify individual amyloid fibril structures using AFM with cryo-EM maps, showing dGAE fibrils are structurally distinct from heparin-induced tau fibrils and related to Alzheimer's PHFs.

DOI 10.1016/j.jmb.2022.167466

cryo-EMimaging

𝕏 PostBluesky

BiochemistrybioRxivDec 7, 2020

Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates.

M. B. Maina, Y. Al-Hilaly, G. B. Burra…·L. Serpell

This study shows that DiY cross-linking promotes tau oligomer formation and prevents filament elongation without causing cell toxicity.

DOI 10.3390/cells10030703

proteomicsexperimental assay

𝕏 PostBluesky