L. Serpell

Generation of an induced pluripotent stem cell line from a healthy adult indigenous Nigerian participant

The paper generates an iPSC line from a healthy Nigerian individual to address the lack of diverse iPSC lines in biomedical research.

The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

The paper compares the aggregation propensity of Tau35 to full-length tau, finding Tau35 aggregates more readily and forms denser structures.

Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates.

This study shows that DiY cross-linking promotes tau oligomer formation and prevents filament elongation without causing cell toxicity.

Dityrosine cross-link trapping of amyloid-β intermediates reveals that self-assembly is required for Aβ-induced cytotoxicity

This study shows DiY cross-linking stabilizes Aβ assemblies but does not induce toxicity, while oligomeric non-cross-linked Aβ is toxic to neuroblastoma cells.

Three-dimensional reconstruction of individual helical nano-filament structures from atomic force microscopy topographs

This paper demonstrates a method to reconstruct 3D structures of individual helical nano-filaments from AFM topographs by using contact-point based deconvolution to overcome tip-sample convolution effects.

Quantification of amyloid fibril polymorphism by nano-morphometry reveals the individuality of filament assembly

This study quantifies amyloid fibril polymorphism using nano-morphometry and AFM, revealing structural heterogeneity and its implications for amyloid assembly and disease.

Formation of functional, non-amyloidogenic fibres by recombinant Bacillus subtilis TasA

This paper shows recombinant Bacillus subtilis TasA forms functional, non-amyloidogenic fibres with properties similar to native fibres, revealing species-specific biofilm matrix assembly requirements.