The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult gut
R. Ramadan, S. M. van Neerven, V. M. Wouters, T. Martins Garcia, V. Muncan, O. D. Franklin, M. Battle, K. S. Carlson, J. Leach, O. J. Sansom, L. Vermeulen, J. P. Medema, D. J. Huels
This study shows that extracellular matrix components, specifically laminin, control stem cell specification and crypt morphology in the gut, with laminin promoting adult stem cell features and crypt-like structures.
bioRxiv · Apr 14, 2021Cell Biology