Author

J. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Bioengineering· 2 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Assay:metagenomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:ecology & biodiversity· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

G. Szeto· 2 shared H. Boukari· 2 shared L. Simpson· 2 shared T. Good· 2 shared A. A. Aksenov· 1 shared A. Aspin· 1 shared A. Bogdanove· 1 shared A. Gonzalez· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBioengineering

G. Szeto

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Early Seasonal Increases and Persistence in Relative Abundance of Potentially Toxic Cyanobacteria: Concerning Impacts of Extended Ice-Free Periods in Northern Temperate Lakes

E. S. Cameron, K. M. Muller, M. Stone, J. Buttle, J. Leach, K. Webster, M. B. Emelko

This study shows that potentially toxic cyanobacteria persist in northern temperate lakes year-round, with increased abundance linked to extended ice-free periods and nutrient availability.

bioRxiv · Dec 20, 2022 · PreprintEcology

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult gut

R. Ramadan, S. M. van Neerven, V. M. Wouters, T. Martins Garcia, V. Muncan, O. D. Franklin, M. Battle, K. S. Carlson, J. Leach, O. J. Sansom, L. Vermeulen, J. P. Medema, D. J. Huels

This study shows that extracellular matrix components, specifically laminin, control stem cell specification and crypt morphology in the gut, with laminin promoting adult stem cell features and crypt-like structures.

bioRxiv · Apr 14, 2021Cell Biology

Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro

M. H. Raymonda, J. H. Ciesla, M. Monaghan, J. Leach, G. Asantewaa, L. A. Smorodintsev-Schiller, M. M. Lutz, X. L. Schafer, T. Takimoto, S. Dewhurst, J. Munger, I. S. Harris

This study identifies lapatinib as a potent antiviral against SARS-CoV-2 in vitro, showing over 50,000-fold inhibition without toxicity.

bioRxiv · Nov 25, 2020Microbiology

Collagen hydrogel confinement of amyloid-β accelerates aggregation and reduces cytotoxic effects

L. Simpson, G. Szeto, H. Boukari, T. Good, J. Leach

This study shows that collagen hydrogel confinement of amyloid-β promotes stable β-sheet aggregates and reduces cytotoxicity compared to 2D cultures.

bioRxiv · Jul 23, 2019Bioengineering

Impact of four common hydrogels on amyloid-β (Aβ) aggregation and cytotoxicity: Implications for 3D models of Alzheimer’s disease

L. Simpson, G. Szeto, H. Boukari, T. Good, J. Leach

This study examines how four hydrogels affect Aβ aggregation and cytotoxicity in 3D models, finding that all hydrogels reduce Aβ toxicity by altering aggregation dynamics.

bioRxiv · Jul 23, 2019Bioengineering

Transfer of Xanthomonas campestris pv. arecae, and Xanthomonas campestris pv. musacearum to Xanthomonas vasicola (Vauterin) as Xanthomonas vasicola pv. arecae comb. nov., and Xanthomonas vasicola pv. musacearum comb. nov. and description of Xanthomonas vasicola pv. vasculorum pv. nov.

D. J. Studholme, E. Wicker, A. Aspin, A. Bogdanove, K. Broders, Z. Dubrow, M. Grant, J. B. Jones, G. Karamura, J. Lang, J. Leach, S. M. Abrare, G. Mahuku, G. V. Nakato, T. Coutinho, , C. Bull

The paper transfers two Xanthomonas species to Xanthomonas vasicola and describes a new pathovar.

bioRxiv · Mar 25, 2019Microbiology

Links between environment, diet, and the hunter-gatherer microbiome

G. K. Fragiadakis, S. A. Smits, E. D. Sonnenburg, W. Van Treuren, G. Reid, R. Knight, A. Manjurano, J. Changalucha, M. G. Dominguez-Bello, J. Leach, J. L. Sonnenburg

The paper examines the microbiome of Hadza hunter-gatherers, finding seasonal changes and unique bacterial families compared to industrialized populations.

bioRxiv · May 15, 2018Microbiology

American Gut: an Open Platform for Citizen-Science Microbiome Research

D. McDonald, E. R. Hyde, J. W. Debelius, J. T. Morton, A. Gonzalez, G. Ackermann, A. A. Aksenov, B. Behsaz, C. Brennan, Y. Chen, L. DeRight Goldasicha, P. C. Dorrestein, R. R. Dunn, A. K. Fahimipourg, J. Gaffney, , Rah

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.

bioRxiv · Mar 7, 2018Microbiology