HBV DNA is a substrate for the cGAS/STING pathway but is not sensed in infected hepatocytes
L. Lauterbach-Riviere, M. Bergez, S. Mönch, B. Qu, M. Riess, F. Vondran, J. Liese, V. Hornung, S. Urban, R. Koenig
This study shows HBV DNA is sensed by cGAS/STING in hepatocytes but is not detected during infection due to capsid shielding, while HBV RNAs are not immunostimulatory.
bioRxiv · Dec 6, 2019Microbiology