V. Hornung

The paper shows that β1 integrin signaling regulates necroptosis through CHD4-mediated repression of Ripk3 in fibrosis.

This study identifies TNF as a necroptosis-associated alarmin by showing that necroptosis promotes TNF translation and release through ADAM protease activation.

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

This study uses super-resolution microscopy to analyze the nanoscale structure of endogenous ASC specks during NLRP3 inflammasome activation, revealing a dense core with extending filaments and changes in density during formation.

The paper shows that C. difficile toxin B activates the NLRP3 inflammasome in human macrophages, not the Pyrin inflammasome, and that Pyrin activation can be restored with prolonged priming.

This study shows HBV DNA is sensed by cGAS/STING in hepatocytes but is not detected during infection due to capsid shielding, while HBV RNAs are not immunostimulatory.

This study shows that NEK7 is not required for NLRP3 activation in human and murine cells under pro-inflammatory conditions when TAK1-dependent priming is active.