M. Bohm

Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.

How much data do we need? Reliability and data deficiency in global vertebrate biodiversity trends

This study assesses the reliability of global vertebrate biodiversity trends by simulating data deficiency and identifying factors affecting trend accuracy.

EDGE2: advancing the prioritisation of threatened evolutionary history for conservation action

The paper introduces EDGE2, an updated metric for prioritizing species with threatened evolutionary history, showing it prioritizes species with fewer close relatives more than the original EDGE method.

A user-friendly guide to using distance measures to compare time series in ecology.

This paper introduces a method to select appropriate distance measures for comparing ecological time series, demonstrating it on UK bird population data.

β-glucan imprinting remodels macrophage function in response to environmental cues

This study shows that β-glucan exposure primes human macrophages to alter their inflammatory responses based on environmental cues, mediated through Dectin-1 and IRF5/IRF3.

Prevalence of sustainable and unsustainable use of wild species inferred from the IUCN Red List

The paper analyzes IUCN Red List data to assess the prevalence of sustainable and unsustainable use of wild species across 30,923 species, finding that 40% are used, with 25% of threatened species at risk due to intentional use.

Global priorities for conservation of reptilian phylogenetic diversity in the face of human impacts

The paper develops metrics combining phylogenetic diversity and human impact for reptile conservation, finding high human impact areas coincide with high reptilian diversity and identifying data-deficient species as high priority.