The Pioneer Transcription Factor Oct4 Differentially Co-opts Bcl11a and Bcl11b to Regulate Reprogramming to Pluripotency
Aneta Trajkova, Emile Zakiev, Maria Grazia Mendoza-Ferri, Ines Messahli, M. Ruel, Imène Krossa, Yann Tapponnier, E. Dejonckere, Emma Hunter, Léo Claret, B. Martin, Nicolas Gadot, F. Forest, Christophe Heinrich, Nadine Martin, , Fabrice Lavial
This study identifies how Oct4 differentially co-opts Bcl11a and Bcl11b to regulate reprogramming to pluripotency by revealing their opposing roles in cell fate conversion.
bioRxiv · Dec 22, 2025 · PreprintCell Biology