M. Hoffmann

A Quantum Lens on Molecular Design: A Machine-Learned Energy Function from Interacting Quantum Atoms.

The paper introduces a machine learning framework to predict accurate energy functions derived from the Interacting Quantum Atoms (IQA) scheme, enabling rapid and interpretable analysis of molecular interactions.

A trait-based metric to prioritise the conservation of functionally irreplaceable species at risk of extinction

This paper introduces a metric called FIRE to prioritize conservation of functionally irreplaceable species at risk of extinction by integrating trait data and extinction risk.

The NAPstar family of NADP redox state sensors highlights glutathione as the primary mediator of anti-oxidative electron flux

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

Mycobacterium tuberculosis infection associated immune perturbations correlate with antiretroviral immunity

The paper shows MTB infection in HIV-positive individuals correlates with immune system shifts and reduced HIV-1 viral load.

Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis

This study shows that serine ubiquitination of p62 by Legionella pneumophila SidE effectors inhibits Nrf2 signaling, altering redox homeostasis and host metabolism during infection.

Evaluating key evidence and formulating regulatory alternatives regarding the UK Hunting Trophies (Import Prohibition) Bill

The paper evaluates evidence for the UK Hunting Trophies (Import Prohibition) Bill, finds trophy hunting is not a major threat but may affect some populations, and suggests regulatory alternatives.

Energetic driving force for LHCII clustering in plant membranes

The paper quantifies the thermodynamic driving force for LHCII clustering in plant membranes using single-molecule measurements and statistical thermodynamics.

Rheological behavior of Pluronic/Pluronic diacrylate hydrogels used for bacteria encapsulation

This study investigates the rheological properties of Pluronic/Pluronic diacrylate hydrogels with varying crosslinking fractions to correlate mechanical behavior with bacterial growth.

TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection

The paper shows TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection in mice, highlighting its role as an antiviral target.

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

A single dose of a recombinant murine CMV vaccine expressing SARS-CoV-2 spike protein provides long-lasting immunity against multiple variants in mice.

SARS-CoV-2 vaccination of laboratory rhesus monkeys (Macaca mulatta): Monitoring and efficacy

This study vaccinates rhesus monkeys against SARS-CoV-2 and shows the vaccination is safe and effective in generating neutralizing antibodies.

Past, present, and future of the Living Planet Index

The paper reviews the evolution of the Living Planet Index, its role in biodiversity monitoring, and its findings of a 68% global vertebrate population decline between 1970 and 2016.

EDGE2: advancing the prioritisation of threatened evolutionary history for conservation action

The paper introduces EDGE2, an updated metric for prioritizing species with threatened evolutionary history, showing it prioritizes species with fewer close relatives more than the original EDGE method.

Selectively expressed RNA molecules: a new dimension infunctionalized cell targeting

The paper develops selectively expressed RNA molecules (seRNAs) that target specific cell types and enable functionalization for therapy, showing efficacy in reducing glioblastoma tumors in mice.

SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

This study identifies camelid heavy-chain-only antibodies that effectively neutralize SARS-CoV-2 and its variants, showing potential for diagnostic and therapeutic applications.

Assessing the global impact of targeted conservation actions on species abundance

This study evaluates the global impact of targeted conservation actions on vertebrate abundance using a counterfactual approach, showing they significantly reduce population decline.

Increased CHIP Prevalence Amongst People Living with HIV

The paper investigates the prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in people living with HIV and finds a higher prevalence compared to controls.

The Omicron variant is highly resistant against antibody-mediated neutralization - implications for control of the COVID-19 pandemic

This study shows the Omicron variant is highly resistant to antibody neutralization, reducing effectiveness of current therapies and vaccines.

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

The paper identifies LRRC15 as a novel host factor that interacts with SARS-CoV-2 spike protein, distinct from ACE2 and other known receptors, and shows it modulates viral infection.

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization

This study shows that intranasal adenoviral vector boosts after mRNA priming enhance mucosal immunity and protection against SARS-CoV-2 in mice.

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

A pair of non-competing neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model

The paper identifies two clusters of non-competing neutralizing antibodies against SARS-CoV-2 that protect mice from infection and weight loss.

Genomic Evidence of Environmental and Resident Salmonella Senftenberg and Montevideo Contamination in the Pistachio Supply-chain

This study analyzes Salmonella contamination in pistachios using genomic data to identify persistent strains and their adaptation mechanisms.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE-2 in vitro

Thiol drugs inhibit SARS-CoV-2 infection in vitro and reduce lung injury in vivo, supporting their potential as COVID-19 treatments.

Prevalence of sustainable and unsustainable use of wild species inferred from the IUCN Red List

The paper analyzes IUCN Red List data to assess the prevalence of sustainable and unsustainable use of wild species across 30,923 species, finding that 40% are used, with 25% of threatened species at risk due to intentional use.

Microplastic fibers affect dynamics and intensity of CO2 and N2O fluxes from soil differently

This study examines how microplastic fibers affect CO2 and N2O emissions from soil, finding increased CO2 and decreased N2O emissions due to changes in soil structure and aeration.

Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesion

This study shows that POMGNT1 deficiency increases N-cadherin levels and alters its N-glycan structures, enhancing cell-cell adhesion and activating EMT-like signaling pathways.

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

This study shows SARS-CoV-2 adapts to Vero E6 cells by losing the furin cleavage motif in spike protein, but retains wildtype sequences, enabling reverse adaptation when passaged on human lung cells.

Improved reference genome uncovers novel sex-linked regions in the guppy (Poecilia reticulata)

The paper presents an improved guppy reference genome using long-read sequencing, revealing novel sex-linked regions and resolving previous contradictions in Y chromosome studies.