Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss
N. Fernando, J. Gopalakrishnan, A. Behensky, L. Reich, C. Liu, V. Bass, M. Bono, W. Montgomery, R. De Pace, M. Mattapallil, V. Nagarajan, S. Brooks, D. Maric, R. Caspi, D. McGavern, H.-Y. Shih
This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.
bioRxiv · Mar 18, 2023 · PreprintImmunology