H.-Y. Shih

This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.

Maternal infection during pregnancy leads to tissue-specific immune changes in offspring through IL-6-induced epigenetic modifications in intestinal epithelial cells.

Natural Killer cells acquire PD-1 from tumor cells via trogocytosis, which inhibits anti-tumor immunity.

This study shows that truncated EIF2B5 expression in zebrafish models of VWM activates the ISR and impairs motor behavior, suggesting a feed-forward mechanism in disease pathophysiology.