Author

V. Nagarajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

R. Caspi· 2 shared A. Behensky· 1 shared A. E. Cohen· 1 shared A. Holmes· 1 shared A. J. St. Leger· 1 shared A. Marson· 1 shared A. S. Brewster· 1 shared A. Zhang· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

R. Caspi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming

W. Zhu, X. Xu, V. Nagarajan, J. Guo, Z. Pent, A. Zhang, J. Liu, M. J. Mattapallil, E. Jittayasothorn, M. Constantinides, R. Horai, Y. Belkaid, A. J. St. Leger, R. Caspi

This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.

bioRxiv · Apr 1, 2024Immunology

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss

N. Fernando, J. Gopalakrishnan, A. Behensky, L. Reich, C. Liu, V. Bass, M. Bono, W. Montgomery, R. De Pace, M. Mattapallil, V. Nagarajan, S. Brooks, D. Maric, R. Caspi, D. McGavern, H.-Y. Shih

This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

J. Lee, M. E. Robinson, R. Sun, K. Kume, N. Ma, K. N. Cosgun, L. N. Chan, E. Leveille, H. Geng, V. S. Vykunta, B. R. Shy, A. Marson, S. G. Katz, J. Chen, E. Paietta, , M. Mueschen

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

bioRxiv · Mar 13, 2023 · PreprintImmunology

Molecular mimicry in deoxy-nucleotide catalysis: the structure of Escherichia coli dGTPase reveals the molecular basis of dGTP selectivity

C. O. Barnes, Y. Wu, J. Song, G. Lin, E. L. Baxter, A. S. Brewster, V. Nagarajan, A. Holmes, M. Soltis, J. Ahn, A. E. Cohen, G. Calero

This paper determines the structure of Escherichia coli dGTPase and elucidates the molecular basis of its dGTP selectivity through comparative analysis with SAMHD1.

bioRxiv · Nov 29, 2018 · PreprintBiophysics