Cell-intrinsic functions of the transcription factor Bhlhe40 in activated B cells and T follicular helper cells restrain the germinal center reaction and prevent lymphomagenesis
R. Rauschmeier, A. Reinhardt, C. Gustafsson, V. Glaros, A. V. Artemov, R. Taneja, R. Mansson, M. Busslinger, T. Kreslavsky
This study shows that Bhlhe40 restrains germinal center reaction in B and T cells, preventing lymphoma by limiting TFH and GC B cell proliferation.
bioRxiv · Mar 12, 2021Immunology