ImmunologybioRxiv
Cell-intrinsic functions of the transcription factor Bhlhe40 in activated B cells and T follicular helper cells restrain the germinal center reaction and prevent lymphomagenesis
R. Rauschmeier, A. Reinhardt, C. Gustafsson…·T. Kreslavsky
This study shows that Bhlhe40 restrains germinal center reaction in B and T cells, preventing lymphoma by limiting TFH and GC B cell proliferation.
DOI 10.1084/jem.20211406