Early invasion of uropathogenic Escherichia coli into the bladder wall by solitary bacteria that are protected from antibiotics and neutrophil swarms in an organoid model
K. Sharma, V. V. Thacker, N. Dhar, F. Signorino-Gelo, M. C. Cabrer, A. Dubois, J. Mullenders, G. Knott, H. Clevers, J. D. McKinney
This study uses a bladder organoid model to show that UPEC can invade deeper bladder layers as solitary bacteria, evading antibiotics and neutrophils, forming reservoirs that contribute to recurrent infections.
bioRxiv · Oct 29, 2020Microbiology