Author

V. V. Thacker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:imaging· 3 Organism:E. coli· 2 Organism:human· 2

Frequent Co-Authors

K. Sharma· 4 shared N. Dhar· 4 shared J. D. McKinney· 3 shared F. Signorino-Gelo· 2 shared A. Dubois· 1 shared G. Knott· 1 shared G. W. Knott· 1 shared G.-F. Mancini· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

K. Sharma

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Author profile →

4 papers

Recent·Most cited

Dynamic persistence of intracellular bacterial communities of uropathogenic Escherichia coli in a human bladder-chip model of urinary tract infections

K. Sharma, N. Dhar, V. V. Thacker, T. M. Simonet, F. Signorino-Gelo, G. W. Knott, J. McKinney

This study uses a bladder-chip model to show that intracellular bacterial communities in UPEC persist despite antibiotic treatment and recovery periods, leading to reinfection.

bioRxiv · Jan 3, 2021Microbiology

A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth in early tuberculosis

V. V. Thacker, N. Dhar, K. Sharma, R. Barrile, K. Karalis, J. D. McKinney

This study uses a lung-on-chip model to show that alveolar epithelial cell-derived surfactant limits early Mycobacterium tuberculosis growth by removing virulence factors.

eLife · Nov 24, 2020Peer-reviewedMicrobiology

Early invasion of uropathogenic Escherichia coli into the bladder wall by solitary bacteria that are protected from antibiotics and neutrophil swarms in an organoid model

K. Sharma, V. V. Thacker, N. Dhar, F. Signorino-Gelo, M. C. Cabrer, A. Dubois, J. Mullenders, G. Knott, H. Clevers, J. D. McKinney

This study uses a bladder organoid model to show that UPEC can invade deeper bladder layers as solitary bacteria, evading antibiotics and neutrophils, forming reservoirs that contribute to recurrent infections.

bioRxiv · Oct 29, 2020Microbiology

Rapid endothelial infection, endothelialitis and vascular damage characterise SARS-CoV-2 infection in a human lung-on-chip model

V. V. Thacker, K. Sharma, N. Dhar, G.-F. Mancini, J. Sordet-Dessimoz, J. D. McKinney

This study shows SARS-CoV-2 directly infects endothelial cells in a lung-on-chip model, causing vascular damage and inflammation independent of immune cells.

bioRxiv · Aug 10, 2020Microbiology