Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions
M. J. Mann, C. Melendez-Suchi, M. Sukhoplyasova, A. R. Flory, M. Carson Irvine, A. Iyer, H. E. Vorndran, C. J. Guerriero, J. L. Brodsky, L. M. Hendershot, T. Buck
This study shows that loss of Grp170 causes ER dysfunction, including BiP misregulation and UPR activation, leading to cell death in mouse embryonic fibroblasts.
Molecular Biology of the Cell · Apr 1, 2024Peer-reviewedCell Biology