Cell BiologyMolecular Biology of the CellPeer-reviewed
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions
M. J. Mann, C. Melendez-Suchi, M. Sukhoplyasova…·T. Buck
This study shows that loss of Grp170 causes ER dysfunction, including BiP misregulation and UPR activation, leading to cell death in mouse embryonic fibroblasts.
DOI 10.1091/mbc.e24-01-0012