Type-I interferons inhibit interleukin-10 signaling and favor type 1 diabetes development in NOD mice
M. Iglesias, A. Arun, M. Chicco, B. Lam, C. Talbot, V. Ivanova, W. P. A. Lee, G. Brandacher, G. Raimondi
This study shows that type-I interferons inhibit IL-10 signaling in T cells, promoting type 1 diabetes in NOD mice by altering T cell responses and spatial localization.
bioRxiv · Feb 1, 2018Immunology