Store Independent Ca2+ Entry Regulates the DNA Damage Response in Breast Cancer Cells
M. R. Makena, M. Ko, A. X. Mekile, D. K. Dang, J. M. Warrington, P. J. Buckhaults, C. Talbot, R. Rao
This study identifies SPCA2 as a driver of chemotherapy resistance in ER+/p53WT breast cancer by suppressing the DNA damage response through store-independent Ca2+ entry.
bioRxiv · Apr 6, 2020 · PreprintCancer Biology