M. Claus

SARS-CoV-2 modulates NK cell responses via induction of HLA-E and triggers expansion of adaptive NK cells during acute infection

This study shows SARS-CoV-2 increases HLA-E expression via spike protein processing, modulating NK cell function by affecting canonical and adaptive NK cells differently during acute infection.

Single-fluorescent protein reporters allow parallel quantification of NK cell-mediated granzyme and caspase activities in single target cells

The paper develops single-fluorescent protein reporters to measure granzyme and caspase activities in individual target cells, revealing a 6-minute delay between granzyme B and caspase-3 activation.