Combined use of design of experiments and metabolic engineering for optimization of nogalamycin production
K. Maki, M. Coe, K. Brown, J. Tran, M. Sohn, E. Nybo
This study uses metabolic engineering and design of experiments to enhance nogalamycin production in Streptomyces nogalater, achieving a fourfold increase in yield through gene overexpression.
bioRxiv · Oct 13, 2019 · PreprintMicrobiology