J. Tran

A Viral-Encoded Homologue of IPS-1 Modulates Innate Immune Signaling During KSHV Lytic Replication

This paper identifies a viral homologue of IPS-1, v-IPS-1, which modulates innate immune signaling during KSHV lytic replication by blocking type I interferon induction.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

CRISPR adaptation in Streptococcus thermophilus can be driven by phage environmental DNA

This study shows that environmental DNA (eDNA) from phages drives CRISPR immunity in Streptococcus thermophilus by enhancing phage-immune colony generation, with effects dependent on phage specificity and environmental conditions.

A multi-track landscape of haematopoiesis informed by cellular barcoding and agent-based modelling

This study uses cellular barcoding and agent-based modeling to reveal clonal fate patterns in hematopoiesis, showing that stem and progenitor cells are often less multipotent than previously thought.

The unusual orf117Sha locus causes desynchronization of pollen development in the Arabidopsis gametophytic Sha CMS

This study identifies orf117Sha as the cause of gametophytic CMS in Arabidopsis, showing pollen death is grain-autonomous and preceded by mitochondrial swelling and developmental desynchronization.

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

A Multi-Epitope/CXCL11 Prime/Pull Coronavirus Mucosal Vaccine Boosts the Frequency and the Function of Lung-Resident CD4+ and CD8+ Memory T Cells and Protects Against COVID-19-like Symptoms and Death Caused by SARS-CoV-2 infection

Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans

This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

Phosphorylation Status of B beta Subunit Acts as a Switch to Regulate the Function of Phosphatase PP2A in Ethylene-mediated Root Growth Inhibition

The paper shows that phosphorylation of Bβ subunit of PP2A acts as a switch to regulate PP2A activity, controlling EIR1 phosphorylation and auxin transport to modulate ethylene-mediated root growth inhibition.

Thermal tolerance and preference are both consistent with the clinal distribution of house fly proto-Y chromosomes

This study shows that male-determining chromosomes in house flies affect thermal tolerance and preference in a way consistent with their clinal distribution across latitudes.

Combined use of design of experiments and metabolic engineering for optimization of nogalamycin production

This study uses metabolic engineering and design of experiments to enhance nogalamycin production in Streptomyces nogalater, achieving a fourfold increase in yield through gene overexpression.

tagPAINT: covalent labelling of genetically encoded protein tags for DNA-PAINT imaging

The paper introduces tagPAINT, a covalent labeling method for DNA-PAINT imaging using genetically encoded protein tags, and applies it to study T-cell receptor signaling proteins.

Alternative Splicing of MR1 regulates antigen presentation to MAIT cells

This study investigates how alternative splicing of MR1 affects antigen presentation to MAIT cells, finding that only MR1A can activate MAIT cells while MR1B inhibits their activation.

Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin α6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC

The paper identifies two survival pathways in bone-metastatic CRPC that confer resistance to PI3K inhibitors and shows combined inhibition of integrin α6β1 and PIM kinase is needed to overcome this resistance.