A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy
K. McGrath, M. Dergai, S. Agarwal, D. Chung, D. B. van Rossum, A. Shevade, S. Kuchin, S. Zaichick, J. N. Savas, D. Fasshauer, G. Caraveo
This study identifies phosphorylation as a regulator of Ykt6 conformational switch in macroautophagy, revealing its role in Ca2+ signaling and implications for Parkinson's Disease.
bioRxiv · Mar 15, 2020 · PreprintCell Biology