D. Chung

Non-catastrophic collapse of VEEV by lethal mutagenesis

This study investigates how Venezuelan Equine Encephalitis Virus (VEEV) responds to RNA mutagen treatment, finding that replication-competent subpopulations persist with lower mutation frequency and increased adaptability.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19

This study shows that combining brequinar and dipyridamole synergistically inhibits SARS-CoV-2 replication in vitro by depleting cellular pyrimidine nucleotides.

Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 Entry

This study identifies small molecule inhibitors of SARS-CoV-2 entry through high-throughput screening and validates Calpeptin as a potent inhibitor of SARS-CoV-2 and some variants.

Network-Based Discovery of Opioid Use Vulnerability in Rats Using the Bayesian Stochastic Block Model

The paper identifies three distinct behavioral sub-populations in rats with varying opioid vulnerability using a Bayesian stochastic block model.

Energy Shortage in Human and Mouse Models of SLC4A11-associated Corneal Endothelial Dystrophies

This study identifies metabolic dysfunction and mitochondrial impairment in SLC4A11-deficient corneal endothelial cells as the cause of dystrophy.

Loss of FSTL1-expressing adipocyte progenitors drives the age-related involution of brown adipose tissue

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier.

This study identifies that Zika virus infects pericytes in the choroid plexus and crosses the blood-CSF barrier to enter the CNS, with CSF neutralization reducing brain infection.

Distinct CD8+ T Cell Programming in the Tumor Microenvironment Contributes to Sex Bias in Bladder Cancer Outcome

The paper identifies sex differences in CD8+ T cell programming in bladder cancer, showing male-biased T cell exhaustion and implications for immune checkpoint therapy.

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy

This study identifies phosphorylation as a regulator of Ykt6 conformational switch in macroautophagy, revealing its role in Ca2+ signaling and implications for Parkinson's Disease.

Accelerated single cell seeding in relapsed multiple myeloma

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

The yellow gene influences Drosophila male mating success through sex comb melanization

This study identifies that the yellow gene affects Drosophila male mating success by altering sex comb melanization, not through neural or behavioral changes.

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.