S. Agarwal

Biological activities and metabolic profile of endophytic Bacillus haynesii from Momordica charantia

This study evaluates the antioxidant and anti-inflammatory potential of an endophytic Bacillus haynesii from Momordica charantia and identifies its bioactive metabolites.

Exploiting gene expression profiles of circulating extracellular vesicles for breast cancer detection

This study identifies five circulating extracellular vesicle RNAs that can diagnose breast cancer independently of subtypes and detect metastatic states.

Kinetics and optimality of influenza A virus locomotion

This study shows influenza A viruses use a burnt-bridge Brownian ratchet mechanism for directed motion through mucus, operating in an optimal parameter range due to evolutionary adaptation.

Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma

This study develops a 3D bone marrow-on-a-chip model to investigate interactions between CAR-T cells and multiple myeloma cells in different niches and assess therapeutic responses.

De Novo TANGLED1 Recruitment to Aberrant Cell Plate Fusion Sites in Maize

The paper shows TANGLED1 is recruited to cell plate fusion sites independently of the preprophase band during cytokinesis in maize.

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

Dormant Mycobacterium tuberculosis reactivates ex vivo in blood from HIV infected individuals

The paper shows that dormant Mycobacterium tuberculosis reactivates in HIV-infected individuals' blood ex vivo, indicated by increased CFUs and upregulated rpf gene expression.

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

Relationship between luteal size and plasma progesterone concentration in pregnant and non-pregnant Indian crossbred dairy cows

This study examines the relationship between luteal size parameters and plasma progesterone concentration in pregnant and non-pregnant Indian crossbred cows, finding luteal area is a better indicator of corpus luteum function.

PAS domain of flagellar histidine kinase FlrB exhibits novel architecture, and binds Heme as sensory signal in unconventional fashion

The paper reports the crystal structure of FlrB's PAS domain and identifies heme as a sensory ligand, showing synergistic binding with ATP to regulate flagellar gene transcription in Vibrio cholerae.

Conformational Tuning Shapes the Balance between Functional Promiscuity and Specialization in Paralogous Plasmodium Acyl-CoA Binding Proteins

This study investigates how sequence differences in paralogous Plasmodium ACBPs shape their conformational behavior and functional promiscuity.

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling

The paper identifies EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling through siRNA screening and pharmacological inhibition.

Propagated circulating tumor cells uncovers the rople of NFκB and COP1 in metastasis

This study develops a CTC and CDX platform to expand patient-derived CTCs and identifies NFκB and COP1 as drivers of metastasis.

Sustained release Resolvin D1 liposomes are effective in the treatment of osteoarthritis in obese mice

This study shows that liposomal Resolvin D1 reduces cartilage damage in obese mice with osteoarthritis by increasing anti-inflammatory macrophages.

The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit

This study identifies a minimal molecular unit composed of Ndc80, Cdt1, and Ska1 that enables processive kinetochore-microtubule coupling during mitosis.

Tumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancer

This study identifies biomarkers beyond B7H3 expression that predict response to a B7H3-ADC in metastatic prostate cancer models, improving therapeutic efficacy.

Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation in animals

This study shows dietary αKG inhibits SARS-CoV-2 infection and reduces lung inflammation and thrombosis in animals, restoring oxygen saturation.

The growth rate of DNA condensate droplets increases with the size of participating subunits

The paper investigates how subunit size affects the growth rate of DNA condensate droplets, finding that larger subunits lead to faster droplet growth.

The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer

This study examines the origin and dynamics of cellular heterogeneity in different subtypes of castrate-resistant prostate cancer using patient-derived organoids and single-cell analyses, identifying distinct lineage plasticity patterns and therapeutic targets.

Zebrafish xenografts to isolate unique human breast cancer metastatic cell populations

This paper develops a zebrafish xenograft model to isolate and study human breast cancer metastatic cells, identifying genes and pathways involved in invasion.

Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

This study develops rapamycin-loaded microparticles that induce autophagy, prevent senescence, and reduce OA symptoms in mice.

Alpha-ketoglutarate augments prolyl hydroxylase-2 mediated inactivation of phosphorylated-Akt to inhibit induced-thrombosis and inflammation

This study shows that alpha-ketoglutarate inhibits Akt-driven thrombosis and inflammation by enhancing PHD2 activity and reducing pAkt1 levels in platelets and leukocytes.

ARID1A-mutant and deficient bladder cancer is sensitive to EZH2 pharmacologic inhibition

This study shows that ARID1A-deficient bladder cancer cells are sensitive to EZH2 inhibition, suggesting a therapeutic strategy for patients with ARID1A mutations.

Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics.

The paper develops a low-cost microfluidic system to separate and enrich sodium-motile bacteria by varying ionic media, achieving eight-fold enrichment of motile populations.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

LFA-1 signals to promote actin polymerization and upstream migration in T cells

This study shows that LFA-1 signaling, but not VLA-4, drives cytoskeletal changes enabling T cells to migrate upstream against shear flow.

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy

This study identifies phosphorylation as a regulator of Ykt6 conformational switch in macroautophagy, revealing its role in Ca2+ signaling and implications for Parkinson's Disease.

Regulation of heterotopic ossification through local inflammatory monocytes in a mouse model of aberrant wound healing

This study identifies TGFβ1-producing monocytes/macrophages as drivers of heterotopic ossification in a mouse model and shows CD47 activation can reduce HO by modulating these cells.