RB1 deletion in RB-pathway disrupted cells results in DNA damage and cancer progression.
A. Marshall, M. Roes, D. T. Passos, M. DeWeerd, A. Chaikovsky, J. Sage, C. Howlett, F. A. Dick
This study shows that RB1 mutations in already compromised RB-pathway cells increase DNA damage and cancer progression through genomic instability and impaired repair mechanisms.
bioRxiv · Mar 23, 2019Cancer Biology