J. Sage

Efficient and multiplexed somatic genome editing with Cas12a mice

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

Development of pre-clinical murine models for fibrolamellar hepatocellular carcinoma

This study develops a novel transgenic mouse model of fibrolamellar hepatocellular carcinoma (FLC) and highlights challenges in establishing ex vivo cell models from FLC tumors.

Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry

This study identifies VM-competent non-neuroendocrine cells in SCLC that support vessel formation and tumor growth through integrin β1-dependent ECM remodeling.

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Progression

This study shows neuronal activity drives SCLC growth in both primary lung tumors and brain metastases through electrical and calcium signaling mechanisms.

Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells

The paper shows that extracellular vesicles from non-neuroendocrine SCLC cells enhance adhesion and survival of neuroendocrine SCLC cells by delivering ECM proteins.

Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation

This study analyzes 3,600 SCLC cases to identify new genetic subtypes and insights into histological transformation, revealing associations between genetic alterations and survival outcomes.

DLL3 REGULATES NOTCH SIGNALING IN SCLC

This study investigates DLL3's role in Notch signaling and SCLC heterogeneity, finding that high DLL3 levels promote a mixed neuroendocrine and non-neuroendocrine cell population.

The cell cycle inhibitor RB is diluted in G1 and contributes to controlling cell size in the mouse liver

This study shows that RB dilution during G1 phase controls cell size in mouse liver by linking cell growth to the G1/S transition.

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC

This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.

Spatial epitope barcoding reveals subclonaltumor patch behaviors

The paper develops a method to track subclonal tumor patch behaviors using spatial epitope barcoding and imaging, revealing emergent properties in cancer cell states.

Measuring mitochondrial electron transfer complexes in previously frozen cardiac tissue from the offspring of sow: A model to assess exercise-induced mitochondrial bioenergetics changes

The paper describes a method to measure mitochondrial electron transfer complexes in previously frozen cardiac tissue from offspring of exercised sows to assess exercise-induced mitochondrial bioenergetics changes.

Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

This study shows that combining anti-GD2 and anti-CD47 antibodies enhances anti-tumor responses by recruiting macrophages and disrupting the GD2:Siglec-7 interaction in GD2+ cancers.

Axon-like protrusions promote small cell lung cancer migration and metastasis

This study identifies axon-like protrusions in SCLC cells as drivers of migration and metastasis, linking neuronal programs to cancer progression.

RB1 deletion in RB-pathway disrupted cells results in DNA damage and cancer progression.

This study shows that RB1 mutations in already compromised RB-pathway cells increase DNA damage and cancer progression through genomic instability and impaired repair mechanisms.

Cyclin D-Cdk4,6 drives cell cycle progression via the retinoblastoma protein’s C-terminal helix

This study shows cyclin D-Cdk4,6 drives cell cycle progression by phosphorylating Rb's C-terminal helix, which is distinct from other cyclin-Cdk interactions and critical for tumor suppression.