Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
L. I. Crouch, D. N. Bolam, A. Basle, C. J. Stewart, M. Wuhrer, R. J. Linhardt, M. V. Liberato, C. A. Lamb, F. Zhang, K. Cooke, M. Doona, S. Needham, R. R. Brady, J. E. Berrington, K. Madunic, , R. Glowacki
The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.
bioRxiv · Nov 9, 2019Biochemistry