A. Basle

Structural basis of iron piracy by human gut Bacteroides

This study reveals the structural mechanism by which Bacteroides thetaiotaomicron steals iron-bound siderophores from pathogens using the XusAB complex.

An ancestral dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes

This study identifies OmpM as a dual-function protein in diderm Firmicutes that tethers the outer membrane to peptidoglycan and facilitates nutrient uptake.

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase

The paper determines cryo-EM structures of human MTHFR bound to SAM and SAH, revealing how inter-domain transformations mediate allosteric regulation by altering active site accessibility.

Structural and biochemical characterisation of the N-Carbamoyl-beta-Alanine Amidohydrolases from Rhizobium radiobacter MDC 8606

This study characterizes the structure and biochemical properties of N-Carbamoyl-beta-Alanine Amidohydrolase from Rhizobium radiobacter MDC 8606, revealing its substrate specificity and potential for industrial applications.

Architecture and regulation of filamentous humancystathionine beta-synthase

This study uses cryo-electron microscopy to reveal how human CBS regulates activity through conformational changes in its regulatory domain.

BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides.

This study identifies stable complexes between BtuB transporters and BtuG lipoproteins in Bacteroides thetaiotaomicron for vitamin B12 uptake via cryoEM, X-ray crystallography, and MD simulations.

Outer membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes

The paper identifies utilisomes as stable glycan-utilising complexes in Bacteroides thetaiotaomicron, revealing their structure and mechanism of substrate capture via cryo-EM.

Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes

The paper identifies D-arabinan degrading enzymes in the human gut microbiome, including new families of glycoside hydrolases and mycobacterial enzymes involved in cell wall degradation.

Structural basis for host recognition and superinfection exclusion by bacteriophage T5

This study reveals the structural basis of host recognition and superinfection exclusion by bacteriophage T5 through cryo-EM and crystal structures of its receptor and SE proteins.

Plant N-glycan breakdown by human gut Bacteroides

The paper identifies a pathway for breaking down plant N-glycans in gut Bacteroides and characterizes enzymes involved, with potential applications in allergen modification and therapeutic protein stability.

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota

This study analyzes carbohydrate sulfatases from Bacteroides thetaiotaomicron, correlating structural and functional data with phylogenetic and environmental analyses to understand sulfated glycan metabolism.

Inositol lipid synthesis is widespread in host-associated Bacteroidetes

This study identifies two pathways for inositol lipid synthesis in host-associated Bacteroidetes, showing their prevalence and potential role in host interactions.

Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment

The paper uses cryo-EM and HDX-MS to analyze an encapsulin nanocompartment, revealing asymmetric cargo loading and dynamic pore behavior.

Structural basis for silicon uptake by higher plants

This study presents the X-ray structure and molecular dynamics simulations of OsNIP2;1, revealing how silicon is taken up by plant roots through aquaporins.

Insights into glycan import by a prominent gut symbiont

This study characterizes the SusCD protein complex in Bacteroides thetaiotaomicron to elucidate its role in glycan uptake, revealing structural and functional insights into ligand binding and transport dynamics.

Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion

The paper shows that Pseudomonas putida F1 uses FadL channels for lateral diffusion of monoaromatic hydrocarbons, bypassing the outer membrane's polar barrier.

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin A-specific role in p27KIP1 degradation

The paper identifies a cyclin A-specific interaction between SKP2 and CDK2-cyclin A complexes that promotes p27KIP1 degradation, distinguishing cyclin A from other G1 cyclins.

Acquisition of ionic copper by a bacterial outer membrane protein

This study identifies OprC as a copper transporter in Gram-negative bacteria, showing it binds both reduced and oxidized copper through a unique metal binding site.

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.

Dynamic oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis

This study identifies RagAB as the oligopeptide transporter in P. gingivalis, revealing its structure and mechanism for nutrient uptake from the extracellular environment.