Author

S. Needham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. Basle· 1 shared A. M. Alonso· 1 shared A. Oniscu· 1 shared A. Waltham· 1 shared C. A. Lamb· 1 shared C. Hayes· 1 shared C. J. Stewart· 1 shared D. I. Spencer· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Basle

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Author profile →

2 papers

Recent·Most cited

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

L. I. Crouch, D. N. Bolam, A. Basle, C. J. Stewart, M. Wuhrer, R. J. Linhardt, M. V. Liberato, C. A. Lamb, F. Zhang, K. Cooke, M. Doona, S. Needham, R. R. Brady, J. E. Berrington, K. Madunic, , R. Glowacki

The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.

bioRxiv · Nov 9, 2019Biochemistry

A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening

R. Gallon, C. Hayes, L. Redford, G. Alhilal, O. O'Brien, A. Waltham, S. Needham, M. Arends, A. Oniscu, A. M. Alonso, S. Moreno-Laguna, H. Sheth, M. Santibanez-Koref, M. S. Jackson, J. Burn

This paper develops a sequencing-based assay using molecular inversion probes to detect microsatellite instability and BRAF V600E mutations in colorectal cancer, enabling high-throughput diagnostics and Lynch syndrome screening.

bioRxiv · Aug 1, 2018 · PreprintCancer Biology