Author

M. Dorel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:experimental assay· 1

Frequent Co-Authors

A. Sieber· 2 shared B. Klinger· 2 shared N. Bluthgen· 2 shared A. Eggert· 1 shared D. Beule· 1 shared E. Blanc· 1 shared F. Eduati· 1 shared F. Hertwig· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

A. Sieber

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2 papers

Recent·Most cited

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

M. Dorel, B. Klinger, T. Mari, J. Toedling, E. Blanc, M. Nadler-Holly, M. Ziehm, A. Sieber, F. Hertwig, D. Beule, A. Eggert, J. H. Schulte, M. Selbach, N. Bluthgen

This study identifies feedback-mediated resistance to MEK inhibitors in neuroblastoma and shows that combining MEK with RAF or IGFR inhibitors can overcome resistance.

bioRxiv · Jun 14, 2021Cancer Biology

Dissecting cancer resistance to therapies with cell-type-specific dynamic logic models

F. Eduati, V. Doldan-Martelli, B. Klinger, T. Cokelaer, A. Sieber, F. Kogera, M. Dorel, M. J. Garnett, N. Bluthgen, J. Saez-Rodriguez

The paper uses dynamic logic models of signaling pathways to predict drug sensitivity in colorectal cancer cell lines and identifies drug combinations to overcome resistance.

bioRxiv · Dec 16, 2016Cancer Biology