T. Cokelaer

This study shows that 5-aminolevulinic acid triggers shutdown of the HemKR signaling system in Leptospira by promoting HemK phosphatase activity, leading to gene expression changes and iron-deficit tolerance.

This study identifies ZCF15 and ZCF26 as biofilm regulators in Candida albicans that modulate metabolic reprogramming during the planktonic-to-biofilm transition.

This paper identifies a bile-induced RND efflux pump in Bacteroides thetaiotaomicron that facilitates magnesium efflux, reducing eDNA concentration and promoting biofilm formation.

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.

This paper characterizes gallocin A, a two-peptide bacteriocin from SGG, showing it requires intramolecular disulfide bonds for activity and that its immunity peptide shares structural features with the toxin.

This study uses target capture sequencing to genotype Leptospira interrogans strains from clinical samples, identifying key serovars with high coverage and accuracy.

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

This study identifies autotransporters as key drivers of biofilm formation and auto-aggregation in Veillonella parvula using genetic tools and functional analyses.

GDSCTools provides a software package for analyzing pharmacogenomic data to identify genomic markers of drug response in cancer.

The paper uses dynamic logic models of signaling pathways to predict drug sensitivity in colorectal cancer cell lines and identifies drug combinations to overcome resistance.