Author

J. Toedling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Eggert· 2 shared A. Steffen· 2 shared B. Gyorffy· 2 shared C. R. A. Regenbrecht· 2 shared D. Henderson· 2 shared D. Mumberg· 2 shared D. Schumacher· 2 shared F. Hertwig· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. Eggert

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

M. Dorel, B. Klinger, T. Mari, J. Toedling, E. Blanc, M. Nadler-Holly, M. Ziehm, A. Sieber, F. Hertwig, D. Beule, A. Eggert, J. H. Schulte, M. Selbach, N. Bluthgen

This study identifies feedback-mediated resistance to MEK inhibitors in neuroblastoma and shows that combining MEK with RAF or IGFR inhibitors can overcome resistance.

bioRxiv · Jun 14, 2021Cancer Biology

Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators EGR2 and SOX2 in Tumorigenesis

J. L. Regan, D. Schumacher, S. Staudte, A. Steffen, R. Lesche, J. Toedling, T. Jourdan, J. Haybaeck, N. Golob-Schwarzl, D. Mumberg, D. Henderson, B. Gyorffy, C. R. A. Regenbrecht, U. Keilholz, R. Schafer, M. Lange

bioRxiv · Feb 2, 2021 · PreprintCell Biology

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence

J. L. Regan, D. Schumacher, S. Staudte, A. Steffen, R. Lesche, J. Toedling, T. Jourdan, J. Haybaeck, D. Mumberg, D. Henderson, B. Gyorffy, C. R. A. Regenbrecht, U. Keilholz, R. Schafer, M. Lange

The paper identifies novel regulators of quiescence in colon cancer stem cells using RNA-sequencing and shows their potential as therapeutic targets.

bioRxiv · Feb 2, 2021Cell Biology

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma

K. Helmsauer, M. Valieva, S. Ali, R. Chamorro Gonzalez, R. Schoepflin, C. Roeefzaad, Y. Bei, H. Dorado Garcia, E. Rodriguez-Fos, M. Puiggros, V. Heinrich, M. Robson, K. Kasack, K. Haase, L. P. Kuschel, , R. P. Koche

The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.

bioRxiv · Dec 20, 2019Cancer Biology