A. Eggert

Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.

Spontaneous helping in pigs is mediated by helper's social attention and distress signals of individuals in need

This study investigates helping behavior in pigs, finding that social attention and distress signals from trapped individuals influence the likelihood of helping.

Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity

The paper investigates how ecDNA copy number heterogeneity affects gene expression and transcriptional states in neuroblastoma cells using single-cell DNA and RNA sequencing.

Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

This paper evaluates elimusertib's preclinical efficacy in pediatric solid tumor models, finding it outperforms standard chemotherapy, especially in alveolar rhabdomysarcoma.

Amplicon structure creates collateral therapeutic vulnerability in cancer

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

This study identifies feedback-mediated resistance to MEK inhibitors in neuroblastoma and shows that combining MEK with RAF or IGFR inhibitors can overcome resistance.

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma

The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.